Determination of the contents of bioactive compounds in St. John’s wort (<i>Hypericum perforatum</i>): Comparison of commercial and wild samples

Abstract St. John’s wort ( Hypericum perforatum ) is a medicinal plant with rich history of traditional use. It has been shown to possess range beneficial health properties, including antioxidant and anti-inflammatory activities. In this study, the content flavonoids activity commercially available dried wild-grown samples were analyzed using LC–MS/MS method. addition, these evaluated for their functional constituents, such as phenolic acids (ferulic, caffeic, chlorogenic, gallic acids), quercetin, rutin, pseudohypericin, hypericin liquid chromatography tandem mass spectrometry The most important constituents in polyphenols chlorogenic acid predominant compound. biocomponents antidepressant was also analyzed. results suggest that wild plants exposed more stress factors have higher amount compounds effects than grown controlled conditions.